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高效液相色谱法测定2,4-二苯基-1,5-苯并硫氮杂-α-(丁二酰亚胺基)-β-内酰胺

Determination of 2,4-dibenzoyl-1,5-benzothiazepine-α-succinimide-β-lactams by high performance liquid chromatography

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【作者】 郝振芳张萍辛云李媛

【Author】 Hao Zhenfang,Zhang Ping,Xin Yun,Li Yuan  (Department of Chemistry,Hebei Normal University,Shijiazhuang 050016)

【机构】 河北师范大学化学系河北师范大学化学系 石家庄050016石家庄050016石家庄050016

【摘要】 建立了测定 2 ,4 -二苯基 - 1,5 -苯并硫氮杂 -α- (丁二酰亚胺基 ) -β-内酰胺高效液相色谱法。该法线性范围在 0~0 .1m g/ m L ,回归方程为 A=196 7346 75 .7c- 35 84 32 .3,相关系数 r=0 .9993,相对标准偏差 0 .38% (c=0 .0 6 mg/ m L ,n=5 ) ,检出限为 0 .0 6μg/ m L。平均回收率在 95 .7%~ 10 3.9%之间

【Abstract】 HPLC method for determination of 2,4 dibenzoyl 1,5 benzothiazepine α succinimide β lactams was developed.Chromatography was carried out on a hypersil ODS 2(4.6mm×250mm,5 μm) column at 254 nm with acetonitrile water (7∶3, V/V ) as mobile phase.The results showed that the calibration curve was linear over a range from 0 to 0.1 mg/mL with a correlation coefficient of higher than 0.9993.The RSD ( n =5) for 0.06 mg/mL compound is 0.38%.Recovery of the method was 95.7%~103.9%.The method was proved to be simple,rapid,accurate and repeatable.

【基金】 河北省自然科学基金资助项目 (2 0 0 15 4)
  • 【分类号】O657.72
  • 【下载频次】33
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