【摘要】 目的　探讨持续非卧床腹膜透析 (CAPD)患者透出液中癌抗原 12 5 (CA12 5)浓度变化的临床意义。方法　用ELISA方法分别检测 2 0例健康对照组人员及 35例CAPD治疗组患者血清CA12 5浓度 ,CAPD治疗组患者透出液CA12 5浓度 ;比较健康对照组与CAPD治疗组患者血清CA12 5浓度的关系 ;分析腹膜炎、透析时间、腹膜转运特性对CAPD患者透出液CA12 5浓度的影响。结果　健康对照组与CAPD治疗组血清CA12 5浓度无显著差异 (P >0 0 5 ) ;腹膜炎组治疗前CA12 5浓度 [(5 8 12± 10 16 )u/ml]显著高于非腹膜炎组 [(34 86± 3 96 )u/ml](P <0 0 1) ,治疗后透出液CA12 5浓度 [(37.5± .16 )u/ml]显著降低 ,与治疗前有显著差异 (P <0 0 1) ,但与非腹膜炎组无显著异 (P >0 0 5 ) ;随着透析时间延长 ,透出液中CA12 5浓度 [逐渐下降 ,两者呈负相关 (r=- 0 .6 7、P <0 0 0 1) ;高腹膜转运组CA12 5浓度 [(46 .86± 9.88)u/ml]与高平均及低平均转运组CA12 5浓度 [(43.96± 7.98)u/ml]之间无显著差异 (P >0 .0 5 )。结论　腹透液中CA12 5主要由腹膜间皮细胞分泌 ;腹膜转运特性对透出液CA12 5浓度无影响 ;动态监测CAPD患者透出液CA12 5浓度变化 ,对于评价腹膜转运功能 ,判断预后有重要意义。更多还原

【Abstract】 Objective To explore the change and significance of serum and diaysate cancer antigen125 (CA 125 ) in patients on continuous ambulatory peritoneal dialysis (CAPD).Methods By using ELISA method to detect the serum CA 125 concentrations in 20,healthy Volunteers and in 35 patients on CAPD and the effluent dialysate CA 125 concentrations in 35 patients on CAPD.To study the relationship of serum CA 125 concertrations between in healthy Volunteers and in patients on CAPD.To analysis the influence of peritonitis, duration of CAPD and peritoneal transport characteristics on the effluent dialysate CA 125 concentrations in patients on CAPD.Results No significent defference was found in serum CA 125 concentrations between healthy Volunteers group and CAPD patients group ( P >0.05).The effluent dialysate CA 125 concentrations in pre peritonitis group [(58.12±10.16)u/ml] was obvious higher than those [(34.86±3.96)u/ml] in stable CAPD patients.The effluent dialysate CA 125 concentrations in post peritonitis group [(37.62±5.16)u/ml] decreased and had a obvious difference from those in preperitonitis group ( P <0.01).The dialysate CA 125 concentrations after recovery from peritonitis were not different from those in stable CAPD patients ( P >0.05);The dialysate CA 125 concentrations decreased gradually with time of CAPD.The dialysat CA 125 concentrations were correlated negatively with the duration of CAPD (r=-0.67, P <0.001);There were no relationships in dialysate CA 125 concentrations between high transport group [(46.86±9.88)u/ml] and high average transport and low average transport group [(43.96±7.89)u/ml].Conclusion The effluent dialysate CA 125 was mainly local introperitoneal produced.There were no relationships between dralysate CA 125 and peritoneal transport parameters Monitoring the dialysate CA 125 concentrations in CAPD patients had important significence to assess the peritoneum function and to adjuge the prognosis.更多还原