【摘要】 目的测量大肠肿瘤细胞核的DNA含量和倍体,计算异多倍体(AN)出现率,探讨其辅助诊断和预测癌变危险度的意义。方法应用HPIAS-1000高清晰度彩色病理图文分析系统,测量60例大肠高分化腺癌、35例绒毛状腺瘤和45例腺管状腺瘤的细胞核DNA含量和倍体计算,AN出现率。结果高分化腺癌、绒毛状腺瘤和腺管状腺瘤的细胞核DNA含量、倍体(U值)及AN出现率两两比较,均有统计学显著性差异。结论在临床病理诊断过程中,DNA含量和倍体的测量对诊断良恶性肿瘤、预测癌变危险度均具有重要的参考价值。更多还原

【Abstract】 ObjectivesTo measure nuclear DNA contents and ploidy of co lo rectal tumors as well as to calculate the rate of AN occurrence and explore thei r roles in the auxiliary diagnosis and prediction of risk grade in malignancy. MethodsNuclear DNA contents and ploidy in sixty cases of highly differentiat ed adenocarcinoma ,thirty-five cases of villous adenoma and forty-five cases of tubular ade-noma were measured by HPIAS-1000-ICM analyzing system fo r highly clear colored pathological illustrations.Their rates of AN oc-currenc e were calculated.ResultsStatistically significant differences in nuclear DNA contents,ploidy and rate of AN occurrence existed among those neoplasms ,a s each pair of two groups was compared.ConclusionIn the process of clinico -pathological diag-nosis,measurement of nuclear DNA contents and ploidy show s important adjunctive value for diagnosis of benign and malignant tu-mors a nd prediction of risk grade in carcinogenesis.更多还原