【摘要】 目的探讨鼻咽癌 (NPC)患者的GSTM1基因多态性。方法采用内参照PCR对NPC患者的基因组DNA进行GSTM1基因型检测。结果NPC患者GSTM1空白基因型频率为 6 0 .0 % ,对照组为 4 5 .0 % ,两者差异有显著性 (P <0 .0 5 ) ,其OR =1.833,95 %CI =1.0 4 6～ 3.14 7;鳞癌的空白基因型频率为 6 0 .5 % ,明显高于腺癌的5 0 .0 % (χ2 =5 .4 0 6 ,P <0 .0 1) ;吸烟者空白基因型个体患鼻咽癌的危险性显著增加 (OR =2 .813,95 %CI=1.35 3～ 6 .0 12 ,P <0 .0 1) ,而不吸烟者的危险性增加不明显 (P >0 .0 5 )。结论GSTM1基因多态性与NPC患者的遗传易感有关 ,与NPC的病理类型也有关 ,吸烟者的GSTM1空白基因型个体更易患NPC更多还原

【Abstract】 ObjectiveTo explore the polymorphism of glutathione S transferase M1(GSTM 1) gene in nasopharyngeal carcinoma (NPC).MethodsThe genetypes of GSTM 1 gene in eighty NPC patients and eighty normal controls were detected by intercontrastive polymerase chain reaction (PCR) technique.ResultsThe frequency of GSTM 1 null genetype in NPC was 60.0%,whereas that in normal controls was 45.0%. The difference between both groups was statistically significant (P< 0.05 , OR=1.833, 95%CI=1.046～3.147); the frequency of GSTM 1 null genetype in squamous cell carcinoma (60.5%) was higher than that in adenocarcinoma (50.0%)(χ 2=5.406,P<0.01); the smokers with null genetype revealed a high risk of NPC (OR=2.813, 95%CI=1.358～6.012,P<0.01),but the non smokers did not(P> 0.05 ). ConclusionsThe polymorphism of GSTM 1 gene is closely related to the genetic susceptibility of NPC patients and the pathological types of NPC. Smokers with GSTM 1 null genotype are more susceptible to suffer from NPC.更多还原