【摘要】 目的 :分析河南省焦作地区痢疾杆菌菌型分布及药物敏感度 ,为临床提供耐药谱。方法 :按细菌检验常规法 ,标本接种SS和麦康凯培养基培养 ,经分离 ,鉴定分型 ,用 14种抗菌药物纸片做药敏试验。结果 :分离出 85株痢疾杆菌 ,福氏志贺氏菌 (B群 )为本地区优势菌 ,占 85 9% ;宋内氏菌 (D群 )占 10 6% ;鲍氏菌 (C群 )占 3 5 % ,在B群中以 2a型居多 ,为 5 7 5 % ,1b型次之 ,为 2 1 9%。药敏试验对一种药物耐药的菌株达 98 8% ,3种以上多重耐药菌为 94 1% ,最多的对 9种药物耐药。其中对四环素 (TET)、链霉素 (STR)、磺胺 (SUL)、红霉素 (ERY)、痢特灵(FU)、氨苄青霉素 (AMP)的耐药率较高 ,分别为 91 8%、81 2 %、77 7%、71 7%、70 6%和 60 % ,对氯霉素 (CMP)为5 1 8% ,复方新诺明 (COS)为 3 2 9% ,属中度敏感。对庆大霉素 (GEN)、先锋霉素 (CTN)、丁胺卡那霉素 (AKN)、新霉毒 (NEO)的耐药率较低 ,分别为 8 2 %、8 2 %、5 9%和 1 2 %。所有 85株试验菌对卡那霉素 (KAN)和妥布霉素(TOB)均敏感。结论 :焦作地区痢疾杆菌耐药比例不断增加 ,要加强抗生素的管理及合理应用 ,并且要及时监测细菌的耐药动态更多还原

【Abstract】 Objective: Analyze the distribution and drug sensitivity of dysentery bacteria in Jiaozuo,Henan Province in order to offer some information for medical workman which drug has no effect.Methods: According to ordinary method of bacterias surveillance put the asmples into ss and makencer culture medium and cultivate it,then abstract and differentiate bacteria types,at last try out the drug senstirity by using 14 sorts of antibiotic drug papers.Results: 85 dysentery bacterias are separated,sh,flexerri is superior to orther bacterias in this district (accounting for 85 9 percent);sh,sconnei (that is 10 6 percent);sh,boydii(that is 3 5%),but there is no sh,dysenteriae.A large number of sh,flexerri is 2a type (which accounts for 57 5 percent),less than 2a type is 1b type (21 9%);The conclusion of drug sensibility experiment:98% strains have drug resistannce on a kind of drug,and 94 1% ones do over three kinds of drugs,even nine kinds of drugs at most.Among them,the freguency of drug resistance on TET?STR?SUL?ERY?FU?AMP is higher than other drugs,which is 91 8%?81 2%?77 7%?71 7%?70 6% and 60% etc.And the frequency of drug resistance on CMP?COS is 51 8% and 32 9%,it is middling.There are less frequency of GEN?CTN?AKN?NEO,which is 8 2%?8 2%?5 9%?1 2% etc.All the 85 strains are sensitive to KAN and TOB.Conclusion: The proportion of no use against dysentery bacteria increases continually,something must be done to manage and make use of antibiotics well and inspect dynamic of unsensitive drugs to bacterias.更多还原