【摘要】 抗生素药物为人类健康做出了突出贡献,而病原微生物抗药性的蔓延、新疾病的涌现等问题向抗生素药物提出了新的挑战. 现代生物及相关科学技术的发展,如基因组学、蛋白质组学、生物信息学、生物大分子结晶技术、药物设计学等,为抗生素药物的研制和开发提供了新的方法与思路.更多还原

【Abstract】 Challenges and opportunities to antibiotics are reviewed. Antibiotics, which have greatly enhanced human health, now are facing the issue of drug resistance of pathogen microbes and newly found diseases. However, modern biotechnology, including genomics, proteomics, bioinformatics and bio-macromolecular crystallization, is providing new ideas and methodology for the research and development of new pharmaceuticals.更多还原