【摘要】 7 -氨基去乙酰氧基头孢烷酸 (7-ADCA)是头孢菌素合成的重要中间体 ,一般以青霉素为原料 ,经氧化 ,扩环 -重排 ,裂解三步反应制备。本文研究用 ρ =2 0 %过氧乙酸作氧化剂 ,反相HPLC监测扩环 -重排反应 ,酰化酶反应裂解的方法。该工艺先进 ,反应温和 ,收率高 ,适合于工业化规模生产。更多还原

【Abstract】 amino deacetoxy cephalosporanic acid (7-ADCA) is a intermediate for cephalosporin, it is prepared from penicillin, via oxidation reaction, ring enlargement and rearrangement reaction and enzymolysis. In this study,20% peroxyacetic acid was used for oxidation, reversion phase HPLC was used to monitor and control ring enlargement and rearrangement reaction,and acylase for hydrolysis to prepare 7-ADCA. This advanced technique was operated under mild condition, with high yield and suitable for industrial production.更多还原