【摘要】 合成了 1 8个含有 1 H-1 ,2 ,4-三唑的咪唑 [2 ,1 -b]-1 ,3 ,4-噻二唑以及 S-三唑 [3 ,4-b]-1 ,3 ,4-噻二唑的稠杂环衍生物 ,经元素分析及谱学表征 ,探讨 2 ,5 ,6-三取代咪唑 [2 ,1 -b]-1 ,3 ,4-噻二唑的可能生成机制 .对大肠杆菌、绿脓杆菌、枯草杆菌等初步抑菌试验证明 ,多数化合物表现了较好的抑菌活性更多还原

【Abstract】 Eighteen novel imidazolo-1,3,4-thiadiazoles and S-triazole-1,3,4-thiadiazoles containing 1H-1,2,4-triazole were synthesized and their structures were confirmed by elemental analyses and spectral analysis. And the characteristic data of 1H NMR and MS were explained reasonably. Furthermore, we also proposed the synthetic mechanism of 2,5,6-substituted-imidazolo-1,3,4-thiadiazole. Primary antibacterial test against E.coli, P.aeruginosa, B.subtilis and S.aureus showed that most of them had good antibacterial activities.更多还原