【摘要】 合成了阿拉伯半乳聚糖修饰的 DTPA钆配合物 ,用红外光谱、元素分析、 ICP-AES等手段进行了表征 ,用竞争性方法研究了其在水溶液中的稳定性 ,测试了其在水中及 BSA溶液中的弛豫性能 ,并进行了体内成像实验 .结果表明 ,其弛豫效率是目前临床所用造影剂 Gd-DTPA的 1 .5～ 2 .0倍 ,对肝脏和肾脏 MRI信号具有良好的增强效果 ,是比较好的潜在磁共振成像造影剂更多还原

【Abstract】 Arabinogalactan-Gd-DTPA was synthesized by the reaction of diethylenetriaminepenta-acetic acid(DTPA) bisanhydride with polysaccharide in dry DMSO and characterized by FTIR, elemental analysis and ICP-AES. Its stability was investigated by competition with Ca 2+, EDTA, DTPA. The t 1-relaxivity is 8.06 mmol -1·L·s -1 in D 2O, 8.48 mmol -1·L·s -1 in 0.725 mmol·L -1 BSA, respectively. t 1-weighted MR imaging of rat kidney and liver showed a remarkable enhancement post injection of Arabinogalactan-Gd-DTPA. The results indicate that the arabinogalactan-Gd-DTPA is a potential contrast agent for MRI.更多还原