【摘要】 目的 了解食盐加碘对哺乳期母亲及婴儿碘营养水平的影响。方法 一次性收集2002年深圳市1所市区和2所农村妇幼医院分娩的哺乳期母亲(连续居住在深圳市3年以上)的乳汁及尿(含男婴尿)、家中食盐。除碘盐采用滴定法测定外,其余样品均采用尿碘的砷铈催化分光光度法测定。结果235份盐碘中位数为32.8mg/kg(范围0.1-83.0mg/kg),90％>15mg/kg;市区和农村盐碘中位数分别为29.6 mg/kg和33.2mg/kg。230份母亲尿碘与215份婴儿尿碘中位数分别为417.2μg/L(范围17.9-1384.0μg/L)和449.4μg/L(范围26.1-1 287.7μg/L)。148份乳汁碘中位数为184.0μg/L(范围8.3-3 909.5μg/L)。市区母亲尿碘、婴儿尿碘、乳汁碘中位数分别为735.0μg/L、721.8μg/L及480.6μg/L.农村则分别为256.1μg/L、117.1μg/L及317.8μg/L,市区均高于农村(P<0.01)。市区母尿与乳汁碘>1000μg/L分别为15.6％和23.2％,婴儿尿碘>800μg/L达41％;而农村母亲乳汁碘尚有39.2％<100μg/L。母亲尿碘和婴儿尿碘、母乳碘和婴儿尿碘均有相关性(r=0.211,r=0.321,均P<0.01)。结论 婴儿高碘与母乳高碘密切相关,母乳高碘与食盐加碘过高有关。在防治IDD的规划中应考虑适宜的食盐加碘量。更多还原

【Abstract】 Objective To determine effect of the iodized salt intervention on iodine nutrition level in breast - feeding mother and newborn. Methods All mothers had lived in the city at least 3 years and their milk, urine and their male - newborn’ s urine were collected at the same time. Milk and urine samples were measured with arsenic - cerium catalyzed spectrophoto technique and iodized salt tested by means of titration neutralization . Results Iodine concentration median of iodized salt (235 samples) was 32.8 mg/kg ( range 0.1 -83.0 mg/kg,90% more than 15mg/kg) , 29.6 mg/kg in urban district and 33.2 mg/kg in rural area. The median of 230 samples of mother was 417.2μg/L (range 17.9 - 1384.0μg/L) , and the median of 215 urine samples of newborn was 449.4μg/L (range 26.1 - 1287.7μg/L ). Milk iodine median of 148 mothers was 184.0 /μg/L (range 8.3 - 3 909.5μg/L) . Iodine median of urine from mother and newborn and milk from mother in urban district was 735.0μg/L , 721.8μg/L and 480.6μg/L respectively; Median in rural area was 256.1μg/L, 117.1μg/L and 317.8μg/L respectively. The corresponding iodine level in city was significantly higher than that in countryside ( P < 0.01) . In urban the percentages of iodine value of urine and milk of mother > 1 000μg/ L were 15.6% and 23.2% respectively and urine iodine of newborn > 800μg/L was 41% , but in rural area milk iodine < 100 (ig/L was 39.2% . Correlation was found between urine iodine of mother and newborn ( r = 0.211 f<0.01), and milk iodine and urine iodine of newborn (r = 0.321 /><0.01). Conclusion Urine iodine of newborn and milk iodine of mother was closely correlated. Too high level iodine in mother milk was related to overdose iodine in iodized salt. The concentration of iodine in iodized salt should be given great concern in IDD intervention program.更多还原