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阳江天然高本底辐射地区居民稳定性染色体畸变的研究

STABLE TYPE CHROMOSOME ABERRATIONS IN THE RESIDENTS OF THE HIGH BACKGROUND RADIATION AREA IN CHINA

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【作者】 王春燕张伟陈德清早田勇南久松真子森岛弥重袁镛龄魏履新菅原努

【Author】 WANG Chunyan 1 ZHANG Wei 1 CHEN Deqing 1 I. Hayata 2M. Minamihisamatsu 2 H. Morishima 3 YUAN Yongling 4 WEI Luxin 1 Sugahara T 5 1(Laboratory of Industrial Hygiene, Ministry of Health, Beijing 100088) 2(Division of Radiobiology and Biodosimetry, National Institute of Radiological Sciences, Japan Chiba 263-8555) 3(Kinki University, Japan Osaka 577-8502 ) 4(Labor Hygiene Institute of Hunan Province, Changsha 410007) 5(Health Research Foundation, Japan Kyoto 606-8225)

【机构】 卫生部工业卫生实验所日本放射线医学综合研究所日本近畿大学原子力研究所湖南省劳动卫生职业病防治研究所日本体质研究会 北京100088北京100088日本千叶263-8555日本东大阪577-8502长沙410007日本京都606-8225

【摘要】 采用了第 1、2、4号全染色体探针 ,以荧光原位杂交 (FISH)技术 ,分析了广东天然高本底辐射地区 (HBRA) 5名儿童和 13名老年男性以及对照地区 (CA) 6名儿童和 11名老年男性淋巴细胞染色体的易位率。与老年人相比 ,儿童染色体的易位率低 ,且变异小 ;而在老年人中个体之间的易位率波动很大。高本底辐射地区居民染色体易位率与对照地区居民相应值比较无显著性差异。没有观察到高本底地区居民和对照地区居民在染色体稳定性畸变 (易位 )频率方面存在差异 ,这一研究结果与流行病学研究结果是一致的。长期的流行病学群组调查没有发现高本底地区存在与高本底辐射有关的癌症危险度增加。

【Abstract】 Chromosome translocations were analyzed by chromosome painting techniques using No.1, 2 and 4 whole chromosome painting probes to examine the effect of high-level natural radiation on the frequencies of chromosome translocations in human peripheral lymphocytes. The subjects were 5 children and 13 old men from the high background radiation area and 6 children and 11 old men from the control area. Children had lesser translocations and smaller variation compared with the old men. The frequency of translocations among the old subjects varied widely from person to person. No difference of the frequency of chromosome translocations between high background radiation area and control area. No effect of high-level natural background radiation on the frequencies of stable chromosome translocation was detected.

【基金】 中日合作研究经费 (卫国合双字 95第 0 30 8号 )资助
  • 【文献出处】 辐射研究与辐射工艺学报 ,Journal of Radiation Research and Radiation Processing , 编辑部邮箱 ,2002年04期
  • 【分类号】Q345
  • 【被引频次】1
  • 【下载频次】47
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