【摘要】 利用联吡啶钌 [Ru(bpy) 3Cl2 ]对几种胺类神经药物的电致化学发光 (ECL)流动注射分析进行了研究。使用改进的流动电解池 ,建立了原位在线的ECL方法 ,提高了检测的灵敏度。在浓度为 0 .0 5mol L的磷酸盐缓冲溶液 (pH =9.0 )中 ,甲基安非它明 (METH)的ECL最强。发光强度与浓度在 6.8× 1 0 - 1 1 ～ 6.8× 1 0 - 3mol L范围内具有良好的线性 ,检出限达 2× 1 0 - 1 6 mol/L ,优越于一般的检测方法 ;比较了METH与安非它明 (APM)的电致化学发光 ;研究了可待因、可卡因、吗啡和咖啡因等毒品的ECL行为 ,并利用循环伏安法对它们不同的发光强度进行了分析。实验结果表明 :该系统简单、方便 ,测定灵敏度高 ,尤其是不需要过氧化物 ,能更方便应用于流动分析体系 ,并为刑侦破案提供了一定的依据。更多还原

【Abstract】 A new electrochemiluminescence (ECL) method for the detection of methamphetamine (METH) and some nervous amine compounds is described. The pH of mobile phase and applied potential on glassy carbon electrode obviously influance the intensity of the ECL of METH. The mobile phase was selected as 0.1 mmpl/L Ru(bpy) 3Cl 2 in 0.05 mol/L NaH 2PO 4 NaOH (pH 9.0) buffer. The studies of the effect of applied potential and flow rate on ECL showed that METH gives the brightest light emission at the potential of +1.55 V and at the flow rate of 0.4 mL/min. A linear relationship was obtained from 6.84×10 -11 ～6.84×10 -3 mol/L with a correlation coefficient of R 2=0.9906 and the detection limit was 2×10 -1 mol/L under the experimental condition. The effect of surfactants on ECL was studied. The work also included the study of ECL of related compounds such as codeine, cocaine, morphine and so on. Cyclic voltammetry showed that their different oxidation currents might lead to their different ECL intensity. The method was simple, economical, sensitive, useful and provided some evidences for scout cases.更多还原