【摘要】 目的 :利用标记免疫分析CA5 0 ,CA12 5 ,CA199和CA15 3水平进行肝癌、结直肠癌、卵巢癌、胰腺癌、乳腺癌、肺癌和胃癌的诊断研究。方法 :标记免疫分析了 6 7例肝癌 ,88例结直肠癌 ,48例卵巢癌 ,36例胰腺癌、乳腺癌 ,12 8例肺癌 ,2 71例胃癌和 6 8例正常对照组。CA5 0 ,CA12 5 ,CA199和CA15 3的批内变异分别为3 7% ,4 8% ,7 6 %和 8 1% ,批间变异分别为 8 1% ,10 1% ,12 3%和 10 4% ,回收率平均介于 95 %～ 10 7%之间。结果 :6 7例肝癌CA5 0 ,CA12 5 ,CA199和CA15 3分别为 40 1± 30 0U/ml,2 8 1± 2 1 2U/ml,11 4± 9 6U/ml和16 2± 8 0U/ml;88例结直肠癌分别为 6 7 8± 45 0U/ml,44 4± 36 1U/ml,6 0 1± 35 8U/m和 2 0 8± 14 8U/ml;48例卵巢癌分别为 40 6± 2 5 1U/ml,180 1± 10 0 2U/ml,15 1± 11 2U/ml和 47 1± 16 4U/ml;36例胰腺癌分别为37 1± 2 2 1U/ml,2 1 8± 14 2U/ml,2 34 2± 6 6 5U/ml和 17 1± 9 1U/ml;34例乳腺癌分别为 10 4± 4 4U/ml,16 4± 9 8U/ml,11 8± 9 8U/ml和 80 1± 36 3U/ml;12 8例肺癌分别为 13 0± 4 6U/ml,10 0 1± 76 4U/ml,12 1±8 8U/ml和 40 3± 18 1U/ml;2 71例胃癌分别为 6 0 6± 40 1U/ml,2 5 7± 18 1U/ml,80 3± 43 2U/ml?更多还原

【Abstract】 Objective To study the diagnosis of liver cancer, coloprocto-caroinoma, overy cancer, pancreatic carcinoma, breas cancer, lung cancer and stomach cancer by labeling immunoassay of CA50, CA125, CA199 and CA153. Methods We had measured the serum content of these tumer markors in 67 liver cancer, 88 coloprocto-carcinoma, 48 orery cancer, 36 pancreatic carcinoma, 34 breast cancer, 128 lung cancer, 271 stomach cancer and 68 normal controls with labeling immunoassay (LIA). The mean coefficient of variation for intra and inter batch-assay of CA50, CA125, CA199 and CA153 were 3.7% and 8.1%, 4.8% and 10.1%, 7.6% and 12.3%, 8.1% and 10.4% respectively. The average recovery ratio was between 95% and 107%. Results The levels of CA50 in stomach cancer and coloproto-carcinoma were signifcantly higher than those in normal controls ( p <0.001). The levels of CA125 in orery cancer and lung cancer were significantly higher than in normal controls ( p <0.001). The levels of CA199 in pancreatic carcinoma cancer was significantly higher than those in normal controls ( p <0 001). The levels of CA153 in breast cancer was significantly higher than those in normal controls ( p <0 001). The mean levels of CA50, CA125, CA199 and CA153 in 68 normal controls were 12.4±3.9U/ml, 14.3±3.9U/ml, 14.3±10.5U/ml, 10.0±8.4U/ml and 15.2±7.5U/ml respectively. Conclusion In present study of 672 cases, CA50 measurement seems to be most useful 1 for diagnosis of gastric and coloprocto-carcinoma, CA125 for ovarian cancer, CA199 for pancreatic cancer and CA153 for breast cancer ( p <0 001).更多还原