【摘要】 目的　用 SD大鼠建立一种简便、易行的血管内皮损伤的动物模型 ,为开展对血管内皮细胞 (VEC)形态及功能作用的体内研究提供基本模型。　方法　按 33.3μg/ 10 0 g的剂量给大鼠皮下注射盐酸肾上腺素 ,3/ d,连续 5天。电镜观察大鼠降主动脉内皮细胞结构变化和血浆内皮素 - 1(ET- 1)浓度改变。　结果　电镜观察制作模型大鼠的 VEC有明显损伤 ,并且血浆 ET- 1浓度显著增高。　结论　用大剂量肾上腺素可以成功的制造血管内皮损伤的大鼠摸型更多还原

【Abstract】 Objective\ To establish a SD rat model of vascular endothelial injury for the study on the morphology and function of vascular endothelial cells(VEC) in vivo.\ Methods\ The model was made by injecting a high dose of adrenaline solution to the SD rat subcutaneously on the dose of 33 3 μg/100 g 3 times per day for continuous 5 days.\ The ultrastructure of VEC in descending aorta was observed by electron microscope and the concentration of endothelin\|1(ET\|1) in plasma was measured.\ Results\ VECs were obviously injured and ET\|1 in plasma increased significantly in the model rats.\ Conclusion\ The rat model of vascular endothelial injury can be established successfully by injection of high dose of \{adrenaline\}. \;更多还原