【摘要】 目的　探讨尿激酶型纤溶酶原激活物 (u PA)在鼻咽癌组织中的表达情况、临床意义以及 型胶原的分布形式。方法　应用免疫组织化学 SP法 ,对石蜡包埋的 80例鼻咽癌标本和 30例慢性鼻咽炎 (对照组 )标本进行检测。　结果　 (1) u PA阳性表达率鼻咽癌组织 (80 .0 % )显著高于对照组 (16 .7% ) (P<0 .0 1) ;(2 )鼻咽癌组织中u PA阳性表达率在 ～ 期 (85 .9% )高于 ～ 期 (5 6 .3% ) (P<0 .0 5 ) ,有颈部淋巴结转移 (87.3% )高于无转移(6 4.0 % ) (P<0 .0 5 ) ;鼻咽癌组织中 u PA阳性表达级别 ～ 期明显高于 ～ 期 (P<0 .0 1) ,有颈部淋巴结转移也明显高于无转移 (P<0 .0 1)。(3)鼻咽癌组织中 型胶原分布均呈崩解缺失型 ,未见包裹型。　结论　 u PA在鼻咽癌组织扩散中起重要作用 ,它与鼻咽癌病期进展和颈部淋巴结转移关系密切 ,可作为判断鼻咽癌恶性度和估计患者预后的生物学指标。更多还原

【Abstract】 Objective To explore the expression, clinical significance of urokinase type plasminogen activator(uPA) and the distribution of collagen type Ⅳ(Col Ⅳ) in nasopharyngeal carcinoma(NPC). Methods 80 cases of nasopharyngeal carcinoma in examined group and 30 cases of chronic nasopharyngitis(CN) as control group were examined with SP immunohistochemistry. Results (1)The positive expression rate of uPA in NPC(80 0%) was significantly higher than that in CN(16 7%, P<0 01). (2)In NPC, the positive expression rate of uPA in Ⅲ~Ⅳ phase(85 9%) was higher than that in Ⅰ~Ⅱ phase(56 3%, P<0 05). It was higher in cases with cervical lymph node metastasis(87 3%) than that in cases without(64 0%, P<0 05). (3)No Col Ⅳ was found in surround tumor nests. Decomposition of Col Ⅳ was a manifestation in NPC. Conclusion uPA expression plays an important role in the spread of NPC. It has a close relation with TNM stage and cervical lymph node metastasis and can be used as an index to determine the malignant degree and to predict the patients’ prognosis.更多还原