【摘要】 目的　判断肺癌的家族危险性 ,探讨遗传因素对肺癌发病的影响。方法　利用遗传流行病学的理论与方法 ,选择并确定了 370例肺癌先证者 ,同时以每位肺癌先证者的配偶为对照且形成对照组。结果　肺癌先证者的亲属 (父母、兄弟姐妹 )患肺癌的危险性是配偶家系亲属 (父母、兄弟姐妹 )的 1.85倍 (P <0 .0 1) ;先证家系的双亲患肺癌和女性亲属患肺癌的危险性分别是配偶家系双亲和女性亲属的 2 .6 6倍和 2 .6 4倍 (P<0 .0 1) ;女性肺癌先证者的双亲患肺癌的危险性是女性对照双亲患肺癌的 2 .2 7倍 (P <0 .0 1)。各种家系分析的结果基本一致。结论　肺癌先证者的亲属对肺癌的易感性比配偶的亲属高 ,遗传因素是肺癌的危险因素之一。更多还原

【Abstract】 Objective To study the familial risk factors on lung cancer and the effect of genetic factors on lung cancer. Methods With methods of genetic epidemiology, 370 probands of lung cancer and 370 spouses of the probands (control) were studied. Results The risk of the probands’ relatives was 1.85 times higher than that of their spouses’ relatives (P<0.01). Compared with the spouses’ parents and female relatives, the OR of the probands’ parents and female relatives was 2.66 and 2.64 (P <0.01), respectively. Compard with the female controls’ parents, the OR of female probands’ parents was 2.27 (P<0.01). Conclusion The susceptibility of the probands’ relatives with lung cancer is higher than that of their spouses’ relatives. The genetic factor is one of risk factors on lung cancer.更多还原