【摘要】 目的　研究葡醛内酯对昆明种小鼠对乙酰氨基酚代谢影响及对对乙酰氨基酚所致的肝损害有无保护作用 .方法　给昆明种小鼠 ip 1 50 mg· kg-1 对乙酰氨基酚及葡醛内酯观察小鼠对乙酰氨基酚代谢速率的改变 .用诱导给药及同时给药法 ip与对乙酰氨基酚等剂量的葡醛内酯观察对对乙酰氨基酚所致的肝损害的影响 .结果　葡醛内酯对昆明种小鼠对乙酰氨基酚代谢无影响 ,对对乙酰氨基酚所致的肝损害也无保护作用 .结论　葡醛内酯对小鼠对乙酰氨基酚毒性无直接解毒作用更多还原

【Abstract】 AIM To study the effect of glucurolactone on metabolism of acetaminophen and whether there is protective effect on liver impairment induced by acetaminophen. METHODS After ip 150 mg·kg -1 acetaminophen and glucurolactone simultaneously, the variation of metabolic ratio was determined. The effect of liver impairment induced by acetaminophen was observed while acetaminophen and glucurolactone were administered ip with inducing or simultane ous administering methods. RESULTS Glucurolactone had no effect on metabolism of acetaminophen and no protecting action on liver impairment induced by acetaminophen in Kunming mice. CONCLUSION Glucurolactone has no direct detoxification to the toxicity induced by acetaminophen in mice.更多还原