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膀胱癌及癌前病变细胞核DNA的测定及临床意义

Determination of DNA in Caryon of Carcinoma of Urinary Bladder and Precancerous Lesion and Its Significance

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【作者】 谢明戴骏胡江辉李徽张伟

【Author】 Xie Ming ,Dai Jun, Hu JiangHui et al. (Affiliated Hospital of Chenzhou Medical College, Chenzhou,Hunan 423000)

【机构】 郴州医专附属医院病理科郴州医专附属第一医院病理科 湖南郴州423000

【摘要】 目的 探讨膀胱癌和癌前病变膀胱乳头状瘤的性质及其生物学行为 ,为临床进一步治疗和预后判断提供病理学依据。方法 应用流式细胞术和细胞图象光度术测量和分析膀胱癌与膀胱乳头状瘤的细胞DNA含量和倍体增殖状态进行比较研究。结果  5 0例膀胱癌细胞的DNA含量和异多倍体出现率较膀胱乳头状癌的DNA含量和异多倍体出现率高出 1倍~ 3倍多。结论 测定膀胱肿瘤中的癌与乳头状瘤DNA含量及倍体测定可作为膀胱肿瘤生物学行为和预后判断的重要指标

【Abstract】 Objective To explore the quality and biologicacal behaviour of carcinoma of urinary bladder and precancerous lesion papilary carcinoma of bladder. Methods Comparison was conducted between carcmo,a of urinary bladder and papilary carcinoma of bladder in the content of DNA and alloploid proliferationg state measured by flow cell count and cytophotometry.Results The content of DNA and incidence rate of allopoly ploid in carcinoma of urinary bladder were one to three times higher than those of papilary carcinoma of bladder.Conclusions The determination of the content of DNA and alloploid can be the important index of carcionoma of urinary bladder.biological behaviour and prognosis judgement.

  • 【文献出处】 郴州医学高等专科学校学报 ,Journal of Chenzhou Medical College , 编辑部邮箱 ,2002年04期
  • 【分类号】R737.14
  • 【下载频次】24
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