【摘要】 目的 :探讨静脉输注长链或中长链脂肪酸脂肪乳剂对急性坏死性胰腺炎 (ANP)大鼠血浆脂质介质及胰腺病理改变的影响。　方法 :雄性SD大鼠 4 3只随机入组 ,A～C为非胰腺炎组 :A组为正常组 ;B组正常大鼠输注脂肪乳剂 ;C组为手术对照组 ,输注葡萄糖液。D～F为ANP模型组 :分别为全糖组 ,Intralipid组和Lipofundin组。测定A组血淀粉酶、前列腺素类 ,胰腺行病理学检查。测定B～F组术后 4、4 8及 72h血淀粉酶、前列腺素类 ,胰腺病理学检查并评分。　结果 :正常大鼠输注Intralipid不引起血前列腺素的变化。在胰腺炎各组 ,脂肪乳剂可提高 4h6 keto PGF1α、PGE2 血浆浓度 ;Lipofundin组胰腺组织的出血和脂肪坏死明显减少。　 结论 :脂肪乳剂不加重ANP大鼠胰腺组织病理损害 ;LCT/MCT脂肪乳剂更适合应用于ANP。更多还原

【Abstract】 Objectives:To investigate the effects of intravenous LCT or MCT/LCT fat emulsions on the lipid mediators and pancreatic histological changes in ANP rats. Methods:Forty three male SD rats were randomized to groups as follow.Group A～C were without ANP, group A:normal controls, group B:normal rats having received lipid based TPN and group C:operation control(OC) group having received the glucose fluid.Group D～F were with ANP,glucose group,Intralipid group and Lipofundin group.The amylase and prostaglandins in serum were determined in group A.Pancreatic histological examinations were also performed.In group B～F,Amylases or prostaglandins in serum were determined at 4,48 and 72 h, and pancreatic histological examination and pathological scoring were also completed. Results:Intralipid had no effects on serum prostaglandins when it was infused to normal rats.In groups of ANP,intravenous fat emulsion increased the 6 keto PGF 1α ,and PGE 2 concentration in serum at 4 h.Pancreatic hemorrhagic and fat necrosis were significantly reduced in Lipofundin group. Conclusions:Intravenous fat emulsion does not worsen the damages to pancreas in ANP.MCT/LCT fat emulsion is more suitable for patients with ANP.更多还原