【摘要】 目的　探讨 6项肿瘤标志辅助诊断肺癌的临床应用价值。方法　采用CEA、NSE、CYFRA 2 1 1、CA12 5、CA 19 9及CA 15 3联合检测 95例肺癌及 4 8例肺结核和肺内其他感染性疾病患者的血清。通过ROC曲线找到最佳临界值并比较几项肿瘤标志物的敏感性、特异性、准确率。结果　除CA 12 5外的其他 5项血清肿瘤标志物在肺癌及其对照组中差异具有显著性。CYFRA 2 1 1对鉴别肺腺癌和肺鳞癌 ,CEA及NSE对鉴别肺腺癌和肺小细胞癌具有一定意义。联合检测可提高诊断的敏感性和准确率。结论　除CA 12 5外的其他 5项血清肿瘤标志在肺癌的辅助诊断中具有重要意义更多还原

【Abstract】 Objective To explore the value of six tumor markers:CEA?NSE?CYFRA 21 1?CA 15 3?CA 12 5?CA 19 9 in the diagnosis of lung cancer.Methods The diagnostic parameters of the tumor markers are presented in 95 patients with lung cancer and compared with a group of 48 patients with respiratory infection of the lung.We determined the cut off points resulting from the best sensitivity specificity balance in the ROC curves.With the cut off we studied the different diagnostic parameters:sensitivity,specificity and accuracy.Results Significant variations were found with all tumor markers but CA 12 5 between the lung cancer and the reference groups.The highest sensitivity is found to be CYFRA 21 1 with 50.53%;CEA specificity with 100%.Conclusions Combination of three or five of these tumor markers may be a useful tool in the diagnosis of lung cancer.更多还原