【摘要】 目的　探讨中国汉族人群中胰高血糖素受体 (GCGR)基因Gly4 0Ser多态性与 2型糖尿病的相关性。方法　采用聚合酶链反应 寡核苷酸连接测定方法 ,对北京地区 10 2对病例 对照配偶对进行GCGR基因Gly4 0Ser多态性基因型检测。结果　病例组和对照组共 2 0 4例样本中均未发现GCGR基因Gly4 0Ser突变。 结论　在中国汉族人群中GCGR基因Gly4 0Ser多态性对 2型糖尿病的发生可能影响不大。更多还原

【Abstract】 Objective To study the relationship between the polymorphism at codon 40 of glucagon receptor gene (GCGR) polymorphism with type 2 diabetes mellitus in Chinese Han population.Methods To evaluate the polymorphism by the polymerase chain reaction(PCR) oligonucleotide ligation assay in 102 pairs case-control spouses in Beijing district.Results None of the 204 Chinese subjects had this mutation.Conclusions GCGR gene seems to play little role in the pathogenesis of type 2 diabetes in Chinese Han population.更多还原