【摘要】 为了探讨阳虚症的发生、发展、转归与环核苷酸系统反应性变化的关系及论证某些助阳药的药理作用 ,对阳虚症组和治疗组小鼠采用RIA测定了血浆cAMP、cGMP及其比值 ,结果表明 :(1)阳虚症组 :阳虚体征明显 ,死亡率高 ,血浆cAMP、cAMP/cGMP比值明显升高 ,提示阳虚症体内的环核苷酸系统反应性是失衡的。 (2 )治疗组 :外观阳虚体征明显改善 ,死亡率下降 ,血浆cAMP明显下降 ,cGMP有所增高 ,cAMP/cGMP比值趋于正常 ,显示体内的环核苷酸系统发生了明显的变化。 (3)测定cAMP及cGMP可作为阳虚症预后的参考指标。 (4)助阳药四逆汤与纠正环核苷酸代谢失调有密切的内在联系更多还原

【Abstract】 To study the relation between Yang Vacuity disease happening, development and cyclic nucleotide response, and prove curative effects of some assisting Yang drug, the plasma cAMP, cGMP and cAMP/cGMP levels were detected by radioimmunoassay in the Yang Vacuity group and curing group. Results showde: (1)Yang Vacuity group: the symptoms were clear, death rate was high, the plasma cAMP and cAMP/cGMP increased obviously, it suggests that cyclic nucleotide was imbalance.(2)Curing group: the symptoms of Yang Vacuity disease were improved obviously, death rate dropped, cAMP declined, cGMP increased, while cAMP/cGMP reached the normal level, it showed that cyclic nucleotide of the body had altered greatly.(3)It is a reference target for Yang Vacuity.(4)Assisting Yang drug ( Sini Decoction)had a close relation with correcting imbalance of cyclic nucleotide.更多还原