【摘要】 利用四氧嘧啶建立糖尿病大鼠模型 ,研究了胰岛素对糖尿病大鼠肝细胞及线粒体氧化损伤的保护作用。结果表明 ,胰岛素 1U kg皮下注射 9d ,能明显降低肝组织谷丙转氨酶、谷草转氨酶、乳酸脱氢酶、黄嘌呤氧化酶的活性 ,显著提高肝组织丙二醛的含量及肝线粒体O· -2 (活性氧自由基 )的生成量 ,显著提高抗氧化酶谷胱甘肽过氧化物酶、超氧化物歧化酶的活性 ,提高肝线粒体H+ ATPase的合成活力 ,从而使受损的肝细胞功能得到改善更多还原

【Abstract】 To observe the effects of insulin on liver and liver mitochondria function in Diabetic rats. Rats were injected iv with alloxan 40?mg/kg to induce diabetes. Insulin 1?U/kg sc daily for 9 days can reduce the activity of GPT,GOT, LDH, XOD, decrease the amount of MDA and improve the activity of liver GSH Px, SOD in liver tissuse obviously and remarkably reduce the production of O ·- 2, improve the synthesis activity of H + ATPase in liver mitochondria of diabetes rats. So Insulin can prevent the injury from superoxide anion in liver and improve the liver function in liver mitochondria of diabetes rats.更多还原