【摘要】 目的 :探讨诱导化疗在中晚期鼻咽癌治疗中的价值。方法 :12 8例Ⅲ、Ⅳa期鼻咽癌随机分为四组 ,每组 32例。A组为单纯放射治疗 (放疗 )组 ;B、C、D组分别为诱导化疗 1、2、3个疗程后可联合与A组相同的放射治疗。四组放疗方法、剂量相同。结果 :放疗结束后鼻咽原发灶、颈淋巴结全消率A、B、C、D四组分别为 :75 .0 %、87.5 %、87.5 %、90 .6 %和 6 8.8%、81.3%、84 .4 %、81.3% ,差异均无显著性 (P >0 .0 5 )。结论 :顺铂、氟尿嘧啶、博来霉素联合诱导化疗合并放射治疗可以提高中晚期鼻咽癌患者的病灶全消率 ,诱导化疗以单疗程为宜更多还原

【Abstract】 Objective:To evaluate induction chemotherapy before radiotherapy for advanced nasopharyngeal carcinoma(NPC).Methods:From March 1996 to June 1999,128 cases of advanced NPC patients were radomized into four groups(32 cases).Group A received radiotherapy alone.Group B,Group C and Group D received induction chemotherapy with cisplatin(60 mg/m\+2,d\-1),5 Fu(500 mg/m\+2,d 1～5 ) and BLM(10 mg/m 2,d 1,3,5 ) for one cycle,two cycles and three cycles respectively,followed by the same radiotherapy.Results:The complete tumor eliminating rates of the primary lesion and cervical node in groups A,B,C,D were 75.0%,87.5%, 87.5 %,90.6% and 68.8%,81.3%,84.4%,81.3%,respectively.The difference was not significant( P > 0.05 ).Conclusions:Induction chemotherapy plus radiotherapy can increase the complete tumor eliminating rates of primary lesion or cervical node and is suitable for one cycle.更多还原