【摘要】 目的 :探讨原发性阴道癌的治疗以及影响预后的相关因素。方法 :对 6 0例原发性阴道癌进行回顾性分析 ;其中 ,单纯放射治疗 2 4例 ,放疗加化疗 2 2例 ,单纯手术 6例 ,手术加化疗 8例。结果 :总 5年生存率 5 8.3%。放疗组和手术组的 5年生存率分别为 5 6 .5 %和 6 4.3% (P >0 .0 5 )。单纯放疗和放疗加化疗的 5年生存率分别为 41.7%和 72 .7% (P >0 .0 5 )。临床分期为Ⅰ、Ⅱ、Ⅲ和Ⅳ期的 5年生存率分别为 83.3%、6 5 .6 %、36 .3%和 0 /5 (P <0 .0 5 ) ;肿瘤浸润阴道≤ 1/3段和 >1/3段的 5年生存率为 76 .9%和 44 .1% (P <0 .0 5 ) ;鳞癌Ⅰ、Ⅱ、Ⅲ级的 5年生存率分别为 83.3%、6 8.2 %和 37.5 % (P <0 .0 5 )。结论 :原发性阴道癌采取彻底的手术治疗或合理的放射治疗 ,均可取得满意疗效。临床分期、病理分级和阴道浸润范围均影响预后更多还原

【Abstract】 Objective:To explore the treatment and prognostic factors of primary carcinoma of the vagina.Methods:Sixty cases of primary vaginal cancer were analyzed,of which 24 were treated with radiotherapy alone,22 with radiotherapy plus chemotherapy,6 with surgery alone,and 8 with surgery plus chemotherapy.Results:The overall 5 year survival rate was 58.2%.The 5 year survival rate of the radiotherapy group was 56.5 %,and the surgery group 64.3%( P >0.05).The 5 year survival rate of stage Ⅰ to stage Ⅳ was 83.3%,65.6%, 36.3 % and 0/5,respectively( P <0.05).The 5 year survival rate of those whose disease was limited to one third of the vaginal canal was 76.9%,and those involved more than one third of the vaginal canal was 44.1 %( P <0.05 ).The 5 year survival rate of squamous cell carcinoma grade Ⅰ to grade Ⅲ was 83.3%, 68.2 % and 37.5% respectively( P <0.05).Conclusions:The results are satisfactory when treated with radical operation or rational radiotherapy.The prognosis of primary carcinoma of the vagina is associated with clinical stage,histologic grade and extent of vaginal canal tumor involvement.更多还原