【摘要】 目的 :观察电针对血管性痴呆 (vasculardementia ,VD)模型大鼠学习记忆能力和局部脑血流量 (regionalcerebralbloodflow ,rCBF)的影响。方法 :用双侧颈总动脉反复缺血 再灌注结合腹腔注射硝普钠法 ,并配合行为学测试确定模型。术后 7d电针百会、大椎、足三里 (双 )治疗。用跳台法评价各组大鼠不同时期的学习记忆能力 ,治疗后测定各组大鼠顶叶及海马rCBF。结果 :VD大鼠在电针治疗后的行为学测试成绩明显提高 (P <0 .0 1) ,其低下的大脑顶叶及海马rCBF水平明显改善 (P <0 .0 1)。结论 :电针对VD大鼠的学习记忆能力有显著的改善作用 ;电针能促使机体低灌流的缺血脑组织灌流水平恢复 ,可能有助于与学习记忆相关的传导环路的修复更多还原

【Abstract】 Objective:To investigate the effect of electroacupuncture(EA) therapy on learning and memory function,regional cerebral blood flow in vascular dementia(VD) rats. Method: VD rat models were established by repeatedly clipping the common carotid artery of the rats in combination with reducing the rat blood pressure with a peritoneal injection of sodium nitroprusside. The models were also screened by the first jumping off latency of step down avoidance test. The VD rats were treated by electroacupuncture at Baihui, Dazhui and Zusanli points. Step down avoidance test recorded the time of latency to evaluate the therapeutic effect. The rCBF in parietal lobe and hippocampus were measured by hydrogen gas clearance method and compared among groups. Result: The scores of the behavior test of the VD rats were obviously increased (P<0.01). Both the rCBF in parietal lobe and hippocampus were significantly improved (P<0.01). Conclusion: The EA therapy can significantly improve the learning and memory function,and increase the level of cerebral blood flow in VD rats.These will be helpful to the recovery of conducting cycle related to learning and memory function.更多还原