【摘要】 目的:比较淋巴与静脉途径化疗对胃癌淋巴结转移灶细胞凋亡的不同影响。方法:随机将同时期进展期胃癌分为二组:淋巴组和静脉组。术中切取胃No6或No7组淋巴结快速冰冻切片证实为转移癌,同时送流式细胞仪检测,随即按组分别经淋巴或静途径给予化疗药物。手术结束时再送转移淋巴结流式细胞仪检测及大体标本病理检查。结果:淋巴组给药前后SPF(S期细胞比例)、APO(细胞凋亡)发生率高度显著性差异(p<0.01):静脉组SPF及APO无显著差异(P>0.05);二组间SPE、APO比较亦有高度显著差异(P<0.01)。结论:淋巴化疗加速淋巴系统肿瘤细胞凋亡,对淋巴结转移灶具有直接治疗作用,静脉化疗则作用甚微。更多还原

【Abstract】 Objective To study the different effects on apoptosis of gastric lympathatic metastatic carcionma induced by lymphatic chemotherapy or by venous chemotherapy. Methods Two groups of advanced gastric carcinoma were divided randomly: lymphatic group and venous group . Flow cytometry examination for No6 or No7 lymph node was done at first , as soon as frozen section confirmed metastatic carcinma lymphatic chemotherapy or venous chemotherapy were carried out according to which group it is in during operation. As operation finished flow cytometry and parhologic examination were done again. Results SPE and APO post -chemotherapy in lymphatic group were signifcant compared with pre-chemotherapy (p<0.01);SEF and APO post-chemotherapy in lymphatic group were also significant compared with post-chemoatherapy in venous group (p<0.01). Conclusion lymphatic chemotherapy can induce apoptosis of lymphatic carcinoma,but venous chemotherapy is weak.更多还原