【摘要】 目的:探讨丹参酮ⅡA（tanshinone Ⅱ A,TSN）对肝脏损伤的保护作用。方法:CCl₄和D-半乳糖胺小鼠肝脏损伤模型,以测定血清谷丙氨酸转换酶（ALT）、谷草氨基酸转换酶（AST）和肝匀浆丙二醛（MDA）含量为指标观察丹参酮ⅡA对肝脏损伤的保护作用。结果:丹参酮ⅡA与阳性对照药联苯双酯相仿,均能明显降低急性肝损伤小鼠的血清ALT、AST和肝匀浆MDA含量。结论:丹参酮ⅡA具有明显的保肝作用。更多还原

【Abstract】 Objective: To study the effect of tanshinone ⅡA on two models of acute hepatic injury in mice. Methods: Two acute hepatic injury models induced by carbon tetrachloride (CCl4) and D-galactosamine (D-GalN) in mice were used. ALT, AST in serum and MDA in liver homogenate were used as indexes. Results: Tanshinone Ⅱ A (10mg·kg-1, 20mg·kg-1, 30mg·kg-1), similar to biophenyldicarboxylate, could decrease ALT, AST in serum and MDA in hepatic homogenate on acute hepatic injury induced by CCl4 and D-GalN. Conclusion: Tan-shinone Ⅱ A possessed obvious protective effect against liver injury induced by CCl4 or D-GalN.更多还原