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养胃抗瘤颗粒对S₁₈₀肉瘤小鼠P⁵³和PCNA表达的影响

Effect of “Yang Wei Kang Liu” Granula on Expression of P⁵³ and PCNA in Mice Bearing Sarcoma 180

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【Author】 Cai Yu (Jiangzhong Pharmaceutical Group Technology Center, Nanchang 330077)Sun Guizi (Guang Anmen Hospital Affiliated on Traditional Chinese Medicine Research Institution, Beijing 100053)

【机构】江中制药集团技术中心；中国中医研究院广安门医院南昌 330077；北京 100053；

【摘要】目的:探讨养胃抗瘤颗粒治疗肿瘤的可能机制。方法:用免疫组化方法研究养胃抗瘤颗粒及其协同化疗在S₁₈₀肉瘤生长过程中对P⁵³和PCNA表达的影响。结果:养胃抗瘤颗粒及其协同化疗均有抑制P⁵³和PCNA表达作用,且两组差异显著（P<0.05）;养胃抗瘤颗粒协同化疗与化疗组比较亦具显著差异（P<0.05）。结论:养胃抗瘤颗粒能抑制P⁵³和PCNA表达,合用化疗作用增强,这可能是该药治疗肿瘤的机理之一。更多还原

【Abstract】 Objective:To study possible mechanism of "Yang Wei Kang Liu" (YWKL) granula in treating tumor.Methods:Mice bearing sarcoma180 and immunohisto-chemical method were adopted.Results: Both YWKL granula and its cooperated chemothrapy could restrain the expression of P53 and PCNA. Compared with the chemotherapy group and the cooperated chemotherapy, YWKL granula group was significantly different. Conclusion: YWKL granula could restrain the expression of P53 and PCNA,and increase the effect together with chemotherapy.更多还原