【摘要】 合成 1 环丙基 6 ,7 二氟 8 甲氧基 1,4 二氢 4 氧代喹啉羧酸乙酯。以 2 ,4,5 三氟 3 甲氧基苯甲酸为起始原料 ,经酰氯化 ,缩合 ,脱羧 ,醚化 ,环丙胺置换 ,环合得本品。实验收率约 48%。本方法制备工艺简单 ,易操作。更多还原

【Abstract】 The 1-cyclopropyl-6,7-difluoro-8-methyl-1,4-dihydro-4-oxoquinoline-3-ethyl carboxylate was prepared by acyl-chlorination,condensation,decarboxylation,estherification,cyclopropylamine replacement and cyclization of 3-methoxyl-2,4,5-trifluorobenzoic acid with an overall yield of 48%.更多还原