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头孢吡肟治疗下呼吸道细菌感染79例
Clinical evaluation of cefepime in treatment of lower respiratory tract bacterial infections
【摘要】 目的 :评价头孢吡肟治疗下呼吸道细菌感染的临床疗效和安全性。方法 :对 79例呼吸道感染患者采用头孢吡肟治疗 ,静脉滴注剂量为 2 .2g/次 ,bid ,疗程 7~ 14d。结果 :治疗总有效率为 86 .1% ,细菌清除率为83 .8% ,不良反应发生率为 1.3%。此外将分离的 6 8株细菌作药敏试验 ,头孢吡肟敏感率为 83 .8% ,对大多数G-杆菌和部分G+球菌敏感 ,与泰能抗菌活性相似 ,较头孢他啶、左旋氧氟沙星和丁胺卡那霉素敏感率高。结论 :头孢吡肟为治疗中、重度下呼吸道感染有效和安全的抗生素
【Abstract】 Objective:To study the efficacy and safety of cefepime in treatment of lower respiratory infections.Methods:79 patients with lower respiratory infections were treated with twice daily of 2.2 g cefepime given by intravenous infusion for 7~14 days.Results:The total effective rate,bacterial eradication rate and the incidence of side effects were 86.1%,83.8% and 1.3% respectively with a susceptibility of 83.8% to 68 bacteria isolated.It has an antimicrobial activities similar to imipenem/cilastatin(Tinam) and more active than ceftazidime,levofloxacin,and amikacin.Conclusion:Cefepime is an effective and safe agent for treatment of lower respiratory tract infections.
【Key words】 cefepime; bacterial infection; antimicrobial activities; clinical efficacy;
- 【文献出处】 中国新药杂志 ,Chinese New Drugs Journal , 编辑部邮箱 ,2001年02期
- 【分类号】R978.1
- 【被引频次】9
- 【下载频次】53