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半夏泻心汤及其拆方对慢性胃溃疡大鼠表皮生长因子的影响

Effects of Banxia Xiexin decoction (半夏泻心汤) and its decomposed recipe on epidermic growth factor in rats with chronic gastric ulcer

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【作者】 王庆国李宇航牛欣赵琰周冠芬贾玉森张冬梅钟相根

【Author】 WANG Qingguo,LI Yuhang,NIU Xin,et al. Beijing Univercity of Chinese Medicine,Beijing 100029

【机构】 北京中医药大学基础医学院!北京100029北?

【摘要】 目的 :对半夏泻心汤进行拆方研究 ,观察其对大鼠慢性胃溃疡模型的治疗作用。方法 :制备大鼠慢性胃溃疡模型 ,检测其表皮生长因子 (EGF)等指标的变化。结果 :半夏泻心汤及其拆方各组均有不同程度的调节胃液中表皮生长因子含量作用。拆方各组中 ,部分药组之间呈协同作用趋势 ,部分药组之间呈制约趋势 ,其中以甘补组 (人参、炙甘草、大枣 )的效果最为显著。结论 :扶正药物在半夏泻心汤中的抗溃疡作用不容忽视。

【Abstract】 Objective:To study the decomposed recipe of Banxia Xiexin decoction (BXXXD,半夏泻心汤) and observe its therapeutic effects on rat models with chronic gastric ulcer.Methods:The rat model with chronic gastric ulcer was established and the changes in indexes of epidermic growth factor(EGF) etc.were detected.Results:All the BXXXD and its decomposed recipe possessed the actions on regulating the contents of EGF in gastric juice to different extent.In decomposed groups some groups showed a tendency towards synergism while others showed restriction.Among decomposed groups the group of tonifying with the sweet (甘补组) displayed the most obvious efficacy.Conclusions:It is certain that the medicines BXXXD,which possess effect of reinforcing the body’s vital energy (扶正) does not allow to ignore.

【基金】 国家自然科学基金资助项目!( No.3 9870 95 0 );国家中医药管理局重点资助项目!( No.972 0 66)
  • 【文献出处】 中国中西医结合急救杂志 ,Integrated Traditional Chinese and Western Medicine In Practice of Critical Care Medicine , 编辑部邮箱 ,2001年03期
  • 【分类号】R285.5
  • 【被引频次】74
  • 【下载频次】775
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