【摘要】 目的 :探讨甲亢患者情绪障碍的特点及抗抑郁剂帕罗西汀对其治疗效果。方法 :收集初诊甲亢患者 82例 ,并对 5 2例伴有抑郁情绪的患者在抗甲亢药物治疗的基础上 ,按随机单盲法分成观察组 2 5例 ,用帕罗西汀 2 0g/日治疗 ,对照组 2 7例未用帕罗西汀治疗 ,观察 8周。结果 :6 3 41%的甲亢患者初诊时伴有抑郁情绪。治疗第四周及第八周发现 ,观察组比对照组抑郁、焦虑分值下降显著 ,观察组患者甲状腺激素TT3、TT4 下降较对照组显著。观察组未见明显副反应。结论 :抗抑郁剂不仅能改善甲亢患者伴有的抑郁、焦虑情绪 ,而且能改善原发病的康复。更多还原

【Abstract】 Objective: To study depression of patients with Grave’s disease and the therapeutic effect of Paroxetine (antidepressant) Method: 82 patients with first onset Grave’s disease were collected and 52 of them had depression The depressive patients were divided into Paroxetine and control group All cases had the same anti-hyperthyroidism treatment Result: 63 4% (52/82) patients with first onset Grave’s disease had depression before Paroxetine treatment After 4 weeks and 8 weeks treatment, Paroxetine group had greater decrease in FT3 and FT4, and lower scores of SDS and SAS than control group (p<0 01) Conclusion: Paroxetine does enhance the therapeutic effect of anti-hyperthyroidism, as well as improving depression of patients with first-onset Grave’s disease更多还原