【摘要】 目的:观察消黄散对实验性大鼠黄疸的作用与作用机理。方法:采用一次性灌胃异硫氰酸α-萘酯(ANIT)中毒制备大鼠黄疸模型,不同剂量消黄散为治疗组,与思美泰对照,观察血清NO、ET及谷丙转氨酶(ALT)、总胆红素(TBil)、γ-谷氨酰转肽酶(GGT)、碱性磷酸酶(ALP)及肝组织病理变化。结果:消黄散和思美泰都能显著改善上述指标(P<0.01),消黄散中、大剂量在某些方面优于思美泰(P<0.01)。结论:消黄散退黄效果肯定。其退黄作用机理之一,可能是通过对NO、ET的影响,从而调节肝脏微循环,达到抗肝损伤,恢复肝脏功能的作用。更多还原

【Abstract】 Objective: To observe the effect and mechanism of Xiaohuang granule on experimental jaundice in rat. Method: The jaundice model of rat was induced by ANIT, treated with Xiaohuang granule or Transemetil. The changes of ALT, TBil, GGT, ALP, NO, ET and pathology of liver tissue were observed. Result: Both Xiaohuang granule and Transemetil could improve above-mentioned indexes (P<0. 01), in some aspect, medium and large dose group of Xiaohuang granule exceled Transemetil group (P<0. 01). Conclusion: Xiaohuang granule has definite effects of eliminating jaundice, can downregulate or upregulate the levels of NO and ET to improving microcirculation of liver , resisting injury to liver, recovering function of liver. The two-way regulation may be the one of mechanism of Xiaohuang granule.更多还原