【摘要】 目的 :探讨湖南地区系统性红斑狼疮患者的遗传易感性基因。方法 :运用PCR -SSO方法分析SLE患者和正常人群中HLADM基因的多态性。结果 :正常人群和SLE人群组中 ,DMA 0 10 1及DMB 0 10 1频率占主要地主 ,DMA 0 10 4和DMB 0 10 4为罕见基因 ,两组之间无显著性差异。结论 :湖南地区SLE患者中未发现HLADM易感基因。更多还原

【Abstract】 Objective:To determine the susceptible genetic factors related to systemic lupus erythematosus in Hunan.Methods:DMA and DMB typing was performed in SLE patients and healthy controls,using PCR-SSO(sequence specific oligonucleotide probes) method.Results:The frequencies of DMA*0101 and DMB*0101 were the predominant alleles in healthy people of Han nationality as well as in SLE patients. DMA*0104 and DMB*0104 were rare alleles.Conclusions: HLA-DM gene has no susceptibility to SLE in Han nationality people of Hunan .更多还原