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TPPA在梅毒临床血清学诊断和室间质评中的应用

Application of Treponema Pallidun Particle Agglutination(TPPA) Test in Clinical Serodiagnos of Syphilis and External Quality Assessment

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【作者】 李介华徐辉

【Author】 LI Jie hua,XU Hui (Department of Laboratory Medicine, The Fifth Affiliated Hospital of Medical College of Jinan University,Qingyuan 511500,China)

【机构】 暨南大学医学院第五附属医院清远市人民医院检验科!广东清远511500

【摘要】 目的 评价 TRUST和 TPPA在梅毒血清学诊断和室间质评中的价值。方法 采用 TRUST和 TPPA检测 80例梅毒患者和 6 7例非梅毒患者血清 ;1998~ 1999年采用 TRUST检测室间质评样本 ,从 2 0 0 0年开始采用 TPPA检测室间质评样本。结果 梅毒患者 TRUST和 TPPA阳性率分别为 86 .3% (6 9/ 80 )与 10 0 % ;TRUST在室间质评样本中的敏感性 44 .44 % ,特异性 90 .0 0 % ,符合率 6 8.75 % ,而 TPPA的敏感性、特异性、符合率达到 10 0 %。两者的敏感性存在明显差别 (χ2 =9.35 ,P<0 .0 1)。结论  TPPA具有很高的敏感性、特异性 ,可作为临床诊断梅毒的首选方法

【Abstract】 Objective To evaluate the value of Tolidime Red Unheated Serum Test (TRUST) and External Quality Assessment.Methods To test the serums of syphilis and non syphilis by TRUST and TPPA.The samples of External Quality Assessment from 1998 to 1999 year and 2000 year were tested by TRUST and TPPA respectively.Results The positive rates of syphilis serum tested by TRUST and TPPA were 86.3%(69/80) and 100%.The sensitivity and specificity of TRUST were 44.44% and 90.00% in External Quality Assessment.The accuracy was 68.75%.The sensitivity and specificity and accuracy of TPPA were all 100%.There was an evident difference between their sensitivties(χ 2=9.35,P<0.01).Conclusions TPPA has very high sensitivity and specificity.It can be first selected clinical method to diagnostic Syphilis.

【关键词】 TPPA/应用血清学诊断梅毒/诊断
【Key words】 TPPA/applyserology diagnosissyphilis/diagnosis
  • 【文献出处】 中国误诊学杂志 ,Chinese Journal of Misdiagnostics , 编辑部邮箱 ,2001年05期
  • 【分类号】R759.1
  • 【被引频次】5
  • 【下载频次】50
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