【摘要】 目的 :为有机磷农药中毒患者寻求新的洗胃液体。方法 :1给大白鼠不同浓度去甲肾上腺素液灌胃 ,观察各浓度去甲肾上腺素液对大白鼠胃粘膜病理学改变 ;2敌敌畏经胃管给狗染毒 ,然后分为模型对照组 (不洗胃 )、实验组 (去甲肾上腺素液洗胃 )和生理盐水组 (生理盐水洗胃 ) ;染毒后每 30分钟监测动物血胆碱酯酶、血压、心率直至 4小时结束。结果 :10 .0 3%去甲肾上腺素灌胃给大白鼠 ,胃粘膜无损伤性改变 ;2实验组犬胆碱酯酶下降程度明显小于模型对照组和生理盐水组 (P均 <0 .0 1)。结论 :10 .0 0 8%～ 0 .0 16 %去甲肾上腺素液洗胃安全 ;2用去甲肾上腺素液体洗胃能减少洗胃时胃内毒物的继续吸收量 ,其中以 0 .0 0 8%去甲肾上腺素液洗胃效果最好。更多还原

【Abstract】 Objective:To seek a new kind of fluid for gastric lavage.Methods:①Rats were treated with gastric noradrenaline lavage in different doses,and histologic change in gastric mucosa was observed.②Dogs were fed with DDVP into the stomach,and animals were allocated into three groups:model control group (without gastric lavage),experimental group (gastric noradrenaline lavage),saline group (gastric saline lavage).Parameters including cholinesterase activity,blood pressure,heart rate were measured from 30 minutes postDDVP up to 4 hours.Results:No abnormal change in gastric mucosa was observed when lavage fluid including noradrenaline content below 0 03% in gastric lavage was used.The decrease in cholinesterase activity was much less in experimental group compared to model control and saline groups (all P <0 01).Conclusions:Gastric noradrenaline lavage in 0 008%～0 016% is safe,and it can markedly decrease continuous absorption of poison,and the best effect was obtained with 0 008% noradrenaline lavage.更多还原