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兔颈总动脉动脉瘤中药白芨胶栓塞研究

Research about Baiji glue embolization for common carotid artery aneurysms in rabbits

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【作者】 丁永红戴大英程瑞新耿坚朱琼黄学箐丁乃时张善生张忠罗其中

【Author】 DING Yonghong,DAI Daying,CHENG Ruixin,et al Department of Radiology,Shuguang Hospital,Shanghai Traditional Chinese Medical University Shanghai,200021

【机构】 上海中医药大学附属曙光医院放射科!上海200021上海同济医院病理科!上海 200321上海中医药大学附属曙光医院放射科!上?

【摘要】 目的 探讨动脉瘤中药白芨胶液体栓塞的可行性。 方法 应用显微外科技术建立10只兔颈总动脉侧壁动脉瘤。将超微导管插至动脉瘤腔并进行中药白芨胶液体栓塞,通过数字减影血管造影及组织病理标本观察栓塞前后瘤腔及载瘤动脉发生的血流动力学改变。 结果 栓塞后即刻血管造影显示7只瘤腔全部闭塞,3只瘤腔大部被白芨栓塞。栓塞后半年组织病理标本示10只动脉瘤瘤腔均完全闭塞,8只动脉瘤远端载瘤动脉通畅,2只动脉瘤远端载瘤动脉闭塞。未见血管壁明显炎症及远端组织缺血表现。 结论 应用中药白芨胶栓塞动脉瘤具有可行性。

【Abstract】 Objective To explore the possibility of Baiji embolization for aneurysms. Method l0 common carotid artery side-wall aneurysms were established by microsurgical technique in rabbits. Ultra-microcatheter was inserted into aneurysm lumen and Baiji liquid was injected to obliterate the aneurysm. Digital subtractive angiography and histopathologic examination were done to observe hemodynamic changes of aneurysm lumen and parent artery. Result 7 aneurysms were completely obliterated immediately after embolization,3 aneurysms were partialy obliterated. After 6 months of embolization,all the l0 aneurysms showed complete obliteration by histopathologic examination,8 parent arteries remained unobstructed,2 distal parent arteries were obliterated,no obvious vessel-wall inflammation and no distal tissue ischemia was found after Baiji glue embolization. Conclusion Baiji glue embolization for aneurysms is possible.

【关键词】 动脉瘤动物模型白芨胶栓塞
【Key words】 aneurysmanimal modelbaiji glueembolization
  • 【文献出处】 中国微侵袭神经外科杂志 ,Chinese Journal of Minimally Invasive Neurosargery , 编辑部邮箱 ,2001年03期
  • 【分类号】R651.12
  • 【被引频次】3
  • 【下载频次】61
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