【摘要】 目的 :比较偏头痛和癫痫患者血清和脑脊液 (CSF)中肿瘤坏死因子α(TNF α)含量 ,以探讨TNF α在偏头痛和癫痫中不同的作用机制的意义。方法 :采用放射免疫测定法 ,对 2 1例偏头痛发作期和 2 0例刚发作后 12小时内的癫痫患者及 19例正常人血清和脑脊液中TNF α进行测定。结果 :( 1)偏头痛组和癫痫组血清和脑脊液中TNF α均较对照组明显升高。 ( 2 )癫痫组血清和脑脊液中含量较偏头痛组明显升高 (均P <0 .0 5)。结论 :偏头痛和癫痫患者存在着免疫紊乱 ,而以后者更明显 ,它们的发病过程中可能均有TNF α的参与。更多还原

【Abstract】 Objective: To compare the contents of tumour necrosis factor alpha(TNF α) in serum and cerebrospinal fluid (CSF) in patients with migraine and epilepsy and to investigate its pathogenetic role in migraine and epilepsy. Method: TNF α was measured by RIA in serum and CSF from 21 patients with migraine and 20 patients with epilepsy and 19 controls with no headache and no epilipsy. Results: (1) Contents of TNF α in serum and CSF in migraine and epilepsy groups were significantly higher than that in control group; (2) Contents of TNF α in serum and CSF in epilepsy group was higher than that in migraine group. Conclusion: Patients with epilepsy and migraine seem to show immunodeficiency, especially in the former, suggesting that TNF α may play a role in the pathogenesis of migraine and epilepsy .更多还原