【摘要】 【目的】探讨补充模拟母乳二十二碳六烯酸 (C2 2∶6,DHA)和二十碳四烯酸 (C2 0∶4 ,AA)水平的脂肪酸对早产儿视功能和认知功能的影响。【方法】选取体质量 <2 10 0 g ,胎龄 <37周的早产儿 32名 ,分为 3组 :A组 ,母乳组 11例 ;B组 ,传统配方组 10例 ;C组 ,补充组 11例。B组配方不含DHA和AA ,C组配方添加了DHA和AA。补充组配方补充至婴儿体质量达(2 5 0± 0 10 )kg。当胎龄满 42周± 1周时以鲍秀兰等新生儿行为神经测定方法测认知功能 ;出生后 3个月时测双眼视网膜电图。【结果】补充组早产儿在视功能、认知功能等方面都与母乳组相近 ,而传统配方组则低于母乳组和补充组 (P <0 .0 5 )。【结论】给予早产儿补充模拟母乳水平的DHA和AA ,可促进其正常的脑发育和视网膜发育 ,使认知功能和视功能与母乳喂养的早产儿相近。更多还原

【Abstract】 Objective To study the effects of docosahexaenoic acid (DHA) and arachidonic acid (AA) intake on the visual and cognitive function of preterm infants. Methods 32 preterm infants (gestational age<37 weeks) were divided into three groups which were fed with different formula respectively: group A, breast milk(n=11); group B, a conventional formula lacking DHA and AA (n=10); group C, DHA and AA enriched formula (n=11). Group C was stopped to fed enriched formula when infant’s weight reached (2.50±0.10) kg. Cognitive function was evaluated by NBNA test when the corrected age of each preterm infant was 42 week±7 day, ERG of both eyes was tested at three-months old. The experiment lasted for three months. Results Cognitive and visual function of group C were similar to group A, however, some indexes of group B were significantly lower than group A and C (P<0.05). Conclusion Adding DHA and AA to formulas similar to breast milk in amounts, can improve cognitive and visual function of preterm infants, and help these infants to achieve similar cognitive and visual function to those breast-milk-fed preterm infants.更多还原