【摘要】 本文应用Wistar大鼠研究了苦参总碱贴片经皮给药后的体内药物动力学 ,由于其它生物碱含量过低 ,故以测定血中苦参碱和氧化苦参碱浓度之和代表苦参总碱 ,计算出药动学参数。结果表明苦参总碱在体内为二室模型一级吸收过程 ,Tp为8 44h ,Cm为 6 5 5 9ug ml,t1 2 α为 5 6 79h ,t1 2 β为 19 5 72h ,t1 2 Ka为 2 831h。更多还原

【Abstract】 Pharmacokinetics in vivo for TTS of total alkaloids of Sophora Flavecens Ait. was studied with Wistar rat and the pharmacokinetics parameters were computed. The rsult showes that it is a kind of 2-compartment model with 1st order absorption.Tp is 8.44hrs,Cm is 6.559ug/ml,t 1/2α is 5.679hrs,t 1/2β is 19.572hrs and t 1/2Ka is 2.83hrs.更多还原