【摘要】 目的　观察藻酸双酯钠 (PSS)治疗大叶性肺炎的疗效及机制。方法　对大叶性肺炎患儿应用PSS治疗 ,观察治疗前后白细胞变形能力 (LD)、粘附功能 (LAF)和肺部呼吸音及X线胸片恢复时间的变化。结果　患儿的白细胞滤过指数 (LFI)和白细胞粘附率 (LAR)明显增高 ,与对照组比较均有显著性差异。PSS治疗组治疗后LFI、LAR明显低于普通治疗组 ,差异有显著性 ;肺部 口罗音和X线胸片恢复时间均明显缩短 ,与普通治疗组比较有显著性差异。结论　PSS具有改善肺部体征 ,提高治疗效果的作用 ,这种作用可能是通过改善LD和降低LAF而实现的。更多还原

【Abstract】 Objective To observe the effect and mechanism of PS S on treating lobar pneumonia.Methods Children with lobar pneumonia were treated with PSS,the cha nges of the leukocyte distortion ability,leukocyte adhesion function,respiratory sounds and chest X-ray before anol after treatment were observed.Results The leukocyte filter index(LFI) and leukocyte adhesion func tion (LAF) in the big focus pneumonia children were obviously higher than those in the health children.There were no significant differences on LFI and LAF betw een the sick children treated by PSS plus common drugs and by common drugs befor e treatment.After treatment,there were obvious drop on LFI and LAF in the sick c hildren treated by PSS plus common drugs than by common drugs.The time recovered from breathing sounds and X-ray examination were obviously shortened in the si ck children treated by PSS plus common drugs than by common drugs.Conclusion The result shows that PSS hasthe function to alter physi cal sign in the lung and to improve treatment results.The function may be carrie d out by improving LD and reducing LAF.更多还原