【摘要】 目的　研究急性白血病患儿反复应用重组粒细胞集落刺激因子 (rhG CSF)的药代动力学及其与临床的关系。方法　应用酶联免疫吸附测定 (ELISA)方法检测 46例白血病患儿的血清G CSF浓度。结果　获得 2 9例患儿用rhG CSF后的标本 ,其血清G CSF浓度为 (5 335± 5 5 97) μg/L。反复应用rhG CSF的患儿在下次用药前血清G CSF水平恢复正常 ;少数未应用rhG CSF患儿可检测到较高浓度的G CSF。血清G CSF浓度与粒细胞绝对计数值呈负相关 (r=- 0 8746 ,P <0 0 1)。结论　rhG CSF的药代动力学中存在有粒细胞介导的清除机制 ,反复应用无药物蓄积作用更多还原

【Abstract】 Objective To investigate the pharmacokinetic progerty after repeated administration of recombinant human granulocyte colony stimulating factor(rhG CSF) in children with acute leukemia and its clinical significance.Methods Serum G CSF concentrations were measured in 46 acute leukemic children by enzyme linked immunosorbent assay.Results The serum G CSF concentration was(5 335±5 597)μg/L in 29 children during rhG CSF treatment . In children received repeted treatment of rhG CSF,serum G CSF levels resumed to normal before next administration.Only few cildren(2/8) who didn’t receive any rhG CSF treatment had higher rhG CSF concentrations;The serum G CSF concentrations correlated negatively with absolute neutrophil counts(r=-0 8746, P<0 01).Conclusion There is a granulocyte-madiating clearing mechanism in rhG CSF pharmacokinetics, and repeated administration of rhG CSF was safe without accumuting effect.更多还原