【摘要】 目的　观察胃癌局部免疫反应细胞与胃癌生物学行为的关系。方法　对 10 7例有 3～ 8年随访资料的胃癌根治性切除标本作局部免疫细胞反应程度的观察。淋巴 -浆细胞反应和嗜酸性白细胞反应用图像分析系统作定量测定 ,肥大细胞在光镜下以个 mm2 作定量计数 ,然后以均数作界值分为高反应组和低反应组 ,并分析与临床病理参数的关系。结果　患者存活时间、肿瘤浸润深度和淋巴结转移情况在胃癌局部免疫细胞反应的高反应组和低反应组间存在显著差异 (P <0 .0 5 )。结论　胃癌局部免疫细胞反应是宿主重要的抗瘤免疫防御机制更多还原

【Abstract】 Objective To study the relationship between the biologic behaviours of gastric carcinoma (GC) and the immune reaction cells of GC tissue. Methods One hundred and seven radical gastrectomy specimens and 3 to 8 years follow up data were quantitatively assessed on the reactive degree of lymph plasma cells and eosinophils with CMIAS image analysis system. Mast cell reaction was accounted in the low power microscopy. Each indicator was divided into two groups, high reaction group and low reaction group, according to the intensity of reactions. Both high reaction and low reaction group were analysed on the base of clinicopathologic parameters. Results There was a significant difference in the survival time, depth of tumour invasion and lymph node metastasis in GC tissue between high reaction group and low reaction group (P<0.05). Conclusions Local immune reaction cells plays an important role in the defense mechanism of GC host against the tumour cells invising and spreading.更多还原