【摘要】 目的探讨胃动素（ＭＯＴ）及血管活性肠肽（ＶＩＰ）与胆囊结石形成的关系。方法收集 ４８例胆囊结石患者术前及术后１、３、７天血浆和胆囊组织、胆汁，采用放射免疫法测定其ＭＯＴ和ＶＩＰ含量。结果胆囊结石患者术前及术后血浆ＭＯＴ水平明显升高；胆囊组织及胆汁中ＭＯＴ、ＶＩＰ水平均明显升高，且胆囊组织中ＭＯＴ与ＶＩＰ呈明显正相关。结论ＭＯＴ和ＶＩＰ可能通过改变胆囊的运动而促进了胆囊结石的形成。更多还原

【Abstract】 Objective To discuss the relationship between motilin, vasoactive intestinal peptide and the gallstone formation. Methods The level of motilin, vasoactive intestinal peptide in plasma. bile and gallbladder tissue of 48 cases of chololithiasis before operation and the first, third, seventh day after cholecystectomy were mesured by radioimmunoassay. Results The level of motilin in plasma was markedly increased in patients with chololithiasis before cholecystectomy and the first day after cholecystectomy The level of motilin, vasoactive intestinal peptide in bile and gallbladder tissue were significantly increased in patients and motilin was positively correlated with vasoactive intestinal peptide in the gallbladder tissue. Conclusion Motilin, vasoactive intestinal peptide might affect the gallstone formation by affecting the motility of gallbladder.更多还原