【摘要】 目的探讨 相代谢酶细胞色素氧化酶基因 (CYP1A1)和 相代谢酶谷胱甘肽转硫酶基因 (GSTM1)多态性与慢性浅表性胃炎危险性的关系。方法用聚合酶链反应 (PCR- SSP)的方法测定慢性浅表性胃炎 10 3例和健康人 6 2例的 CYP1A1和 GSTM1基因型 ,采用非条件 L ogistic回归模型分析其与慢性浅表性胃炎危险性的关系。结果在调整年龄、性别、文化程度和职业因素后 ,没有发现 CYP1A1、GSTM1基因与慢性浅表性胃炎有关联 ,但CYP1A1G/ G与幽门螺杆菌感染间有明显的协同作用。更多还原

【Abstract】 Objective To explore polymorphisms of CYP1A1 and GSTM1 genes related with the susceptibility to chronic superficial gastritis. Methods 103 chronic superficial gastritis and 62 healthy persons were diagnosed by histopathology from Jan.1988 to Jan.2000 in the affiliation hospital of Shandong Medical Univeristy.The gene polymorphisms were detected by polymerase chain reaction of sequence-specific primer method.The unconditional Logistic method was used in the data analysis of this case-control study.Results After adjusting age,sex,educational levels and profession,there was no relationships founded between CYP1A1 & GSTM1 genes and the chronic superficial gastritis.However,there was an interaction effects between CYP1A1 G/G and the infection of Helicobacter Pylori(HP).Conclusion The CYP1A1 G/G genotype and HP infection may be associated with susceptibility to chronic superficial gastritis.更多还原