【摘要】 目的　评价防治骨质疏松症大鼠模型药物疗效的各项指标。方法　采用卵巢切除术建立骨质疏松症预防和治疗大鼠模型 ,分别灌喂阿仑膦酸钠和埃本膦酸钠 ,持续处理 6个月。以骨密度、骨生化标志物、骨矿含量、骨生物力学和骨组织形态学方面的参数为指标 ,评价它们的价值。结果　两组大鼠模型用药后 ,各部位的骨密度明显升高。评价药物疗效时 ,敏感度、特异度、准确度最高的是全身骨密度和骨小梁面积。用药大鼠的股骨最大弯曲载荷、骨挠度、股骨干重、灰重、骨钙含量虽有不同程度的增高 ,血清骨钙素有一定程度的下降 ,但与对照组相比基本均无统计学意义。结论　全身骨密度是评价防治骨质疏松症药物疗效的最佳指标 ,骨切片计算骨小梁面积也是评价防治骨质疏松症药物疗效的敏感指标。更多还原

【Abstract】 Objective To evaluate the i ndexes for prevention and treatment of osteoporosis on rat models. Me thods The rat models of osteoporosis were established by ovariectom y and divided into two groups: prevention group and treatment group, which were p o administered with Alenbronite or Ibinbronite for six months respectively. The bone mineral density, bi ochemical markers, bone mineral contents, physical parameters and bone trabecula e areas were measured and analyzed.Results The bone miner al density of all the rats increased significantly after administration. The res ult indicated that the bone mineral density and bone trabeculae area were of mor e sensitivity, specificity and accuracy on analyzing osteoporosis than other par ameters. Conclusion The bone mineral density is the optim al index to evaluate the curative effects on osteoporosis and the bone trabeculae area is another sensitive index too.$$$$更多还原