【摘要】 目的 :为了进行抗移植排斥反应药物的筛选 ,建立异种心脏移植模型。方法 :采用小鼠心脏主动脉和肺动脉异位与大鼠肾脏动脉和肾静脉端 端吻合 ,共进行预实验 10次 ,正式实验 5次 ,成功 4次。结果 :平均心脏成活时间 ( 77.5 5± 4.6 0 )h。结论 :该方法简单、快速、可靠 ,适用于异种移植和抗排斥药物的筛选。更多还原

【Abstract】 Objective: In order to identify the function of the agents of anti-graft rejection, we established a cardiac xenotransplantation model between rat and mouse. Methods: The mouse heart was transplanted into the rat abdomen. The graft of the aorta to the host kidney artery and the graft of the pulmonary artery to the host kidney vein were performed. After 10 preparatory experiments, we did 5 formal transplantation experiments among which 4 were successful. Result: The mean survival time was (77.55±4.60) hours. Conclusion: The method is easy, quick, reliable and suitable for the anti-graft rejection agents or drugs selecting.更多还原