【摘要】 目的 :探讨胃癌组织中nm2 3 蛋白的表达与癌组织微血管密度与转移的关系。方法 :用免疫组织化学LSAB方法检测 85例胃癌癌组织微血管 (MVD)及nm2 3 蛋白的表达 ;在第Ⅷ因子相关抗原 (FⅧRAg)染色切片上检测其微血管密度。结果 :nm2 3 表达阳性淋巴结转移率明显低于nm2 3 表达阴性组 ,而且差异有显著性。nm2 3 表达阳性组与阴性组比较 ,nm2 3表达与MVD呈负相关。结论 :nm2 3 基因受抑制时 ,MVD增加 ,淋巴结转移率增高。因此时nm2 3 及MVD的检测 ,可作为预测胃癌转移及判断预后的可靠指标之一。更多还原

【Abstract】 Objective:To study the relationship between nm 23 protein expression and interstitial microvascular density(MVD) and its metastasis in gastric carcinoma. Methods:The expression of nm 23 protein and FⅧRAg were detected and analyzed in 85 cases of gastric carcinoma with immunohistochemical technique.Results:A significant difference in lymph node metastasis exists between nm 23 protein expression and MVD expression.Conclusion:When the expression of nm 23 protein was inhibited,MVD expression increased and was positively related with lymph node metastasis.Therefore,To detect nm 23 protein and microvascular density may be the reliable makers for predicting gastric cacinoma metastasis and prognosis.更多还原