【摘要】 目的 :探讨一氧化氮 (NO)在氟骨症发病学中的作用。方法 :健康SD大鼠分为对照组 (饮蒸馏水 )、低剂量过量氟组 (饮水含氟 5 0mg .L-1)、高剂量过量氟组 (饮水含氟 10 0mg .L-1) ,分别于实验后 10周和 2 0周测定大鼠血清游离氟和NO含量、骨氟含量及胫骨纵径、横径 ,观察胫骨骺板软骨组织细胞学变化。结果 :随摄氟量的增加及染氟时间的延长 ,大鼠血清游离氟、NO含量和骨氟含量增加 ,胫骨纵径、横径减短 ,胫骨骺板软骨出现明显病理变化 ;实验大鼠血清NO含量与血清游离氟和骨氟含量及骺板软骨损伤程度呈显著正相关 ,和胫骨纵径横径呈显著负相关。结论 :NO很可能在氟骨症早期骨软骨损伤中起一定的介导作用。更多还原

【Abstract】 Objective:To investigate the role of nitric oxide(No) in pathogenesis of skeletal fluorosis(SF).Methods:The healthy SD rats were divided into the control group(intaked the distilled water),the low dose excess fluoride(EF)group(intaked the 50mg.L -1 F -water)and the high dose EF group(intaked the 100mg.L -1 F -water).In the 10 th and the 20 th weeks from the beginning of the experiment,NO and free fluorine contents in serum,fluorine contents in bone and tibial length and width were assayed,the morphological changes in the growth plate cartilage(GPC)of tibia were observed in rats.Results:Following dosage of EF and experimental period,NO and free fluorine contents in serum,fluorine contents in bone were increased,the length and width of tibia were shortened,and the tibial GPC were showed pathologic damages in rats treated with EF.There was a positive correlation between NO contents and free fluorine contents in serum,fluorine contents in bone and the damage severity of tibial GPC,and a negative correction between NO contents and the length and width of tibia.Conclusion:NO may play an inducing role in the early damage of cartilage and bone on SF.更多还原